Affected sib pair method for searching major gene in multifactorial disease
نویسندگان
چکیده
منابع مشابه
A new transmission test for affected sib-pair families
Family-based association approaches such as the transmission-disequilibrium test (TDT) are used extensively in the study of genetic traits because they are generally robust to the presence of population structure. However, these approaches necessarily involve recruitment of families, which is more costly and time-consuming than sampling unrelated individuals in the population-based approaches. ...
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Now, many human genetist are trying to detect agent loci of common diseases, such as hypertension, diabetes, heart disease, multiple sclerosis, arthritis, obesity, and so on. These diseases are caused by multiple genes interacting with each other and with environmental factors to create a gradient of genetic susceptibility to disease. Even when a trait is governed by multiple disease genes, for...
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Two widely used affected-sib-pair scoring procedures (the Green and Woodrow [1977] procedure, and the method of forming all possible affected-sib-pairs) are compared with a new method for their relative efficiency in detecting the presence of an HLA-linked disease susceptibility gene. Their relative performance is investigated by extensive computer simulations over a large number of disease tra...
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An improved sib-pair test for linkage is introduced which is superior to the previously proposed tests. The test is derived from the standard chi-squared goodness of fit statistic by restricting the alternative hypothesis to the genetically possible. Critical values are given and exact power comparisons are made with the previously proposed tests. The new test is shown to be more powerful for f...
متن کاملAffected-sib-pair interval mapping and exclusion for complex genetic traits: sampling considerations.
We describe an extension of Risch's [(1990a,b) Am J Hum Genet 46:222-228, 229-241] method of linkage detection and exclusion for complex genetic traits. The method uses interval mapping to infer disease locus identity-by-descent (IBD) sharing for affected sib pairs (ASPs) based on marker information for the ASP and other genotyped family members. The method is likelihood based, and makes use of...
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ژورنال
عنوان ژورنال: Japanese journal of human genetics
سال: 1982
ISSN: 0021-5074
DOI: 10.1007/bf01900442